WebKrüppel-like factor 4 (KLF4), a zinc-finger transcription factor that suppresses inflammatory signals, is an essential regulator of macrophage polarization in adipose tissues, but the … WebAug 9, 2024 · Macrophages are very important immune cells and play critical roles in tumour immunity. Macrophage subtypes can be divided into classical polarization (M1 macrophages) and alternative polarization (M2 macrophages) under different microenvironments. Krüppel-like factor 4 (KLF4) is an essential transcription factor for …
Myeloid Krüppel-like factor 2 is a critical regulator of
WebApr 30, 2024 · As such, it is possible that kidney-derived CSF2 induces KLF4-dependent resident macrophage proliferation. Future studies will be needed to delineate the detailed mechanisms by which KLF4 regulates … WebJun 13, 2011 · KLF4 is essential for IL-4–mediated macrophage M2 polarization. ( A) Impairment of M2 marker gene expression in KLF4-deficient macrophages. PMs isolated … foot injuries bottom of foot
Role of Kruppel-like factor 4 in atherosclerosis - ScienceDirect
WebJun 13, 2011 · Macrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human inflammatory paradigms in vivo. Mechanistically, KLF4 was found to cooperate with Stat6 to induce an M2 genetic program and inhibit M1 targets via sequestration of coactivators … WebKLF4 may promote inflammation by mediating NF-κB-dependent inflammatory pathway such as in macrophages, esophageal epithelium and in chemically-induced acute colitis in … WebJul 23, 2024 · Background. Polarized macrophage populations can orchestrate both inflammation of the kidney and tissue repair during CKD. Proinflammatory M1 macrophages initiate kidney injury, but mechanisms through which persistent M1-dependent kidney damage culminates in fibrosis require elucidation. Krüppel-like factor 4 (KLF4), a zinc … elevate whangarei