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Klf4 macrophage

WebKrüppel-like factor 4 (KLF4), a zinc-finger transcription factor that suppresses inflammatory signals, is an essential regulator of macrophage polarization in adipose tissues, but the … WebAug 9, 2024 · Macrophages are very important immune cells and play critical roles in tumour immunity. Macrophage subtypes can be divided into classical polarization (M1 macrophages) and alternative polarization (M2 macrophages) under different microenvironments. Krüppel-like factor 4 (KLF4) is an essential transcription factor for …

Myeloid Krüppel-like factor 2 is a critical regulator of

WebApr 30, 2024 · As such, it is possible that kidney-derived CSF2 induces KLF4-dependent resident macrophage proliferation. Future studies will be needed to delineate the detailed mechanisms by which KLF4 regulates … WebJun 13, 2011 · KLF4 is essential for IL-4–mediated macrophage M2 polarization. ( A) Impairment of M2 marker gene expression in KLF4-deficient macrophages. PMs isolated … foot injuries bottom of foot https://jjkmail.net

Role of Kruppel-like factor 4 in atherosclerosis - ScienceDirect

WebJun 13, 2011 · Macrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human inflammatory paradigms in vivo. Mechanistically, KLF4 was found to cooperate with Stat6 to induce an M2 genetic program and inhibit M1 targets via sequestration of coactivators … WebKLF4 may promote inflammation by mediating NF-κB-dependent inflammatory pathway such as in macrophages, esophageal epithelium and in chemically-induced acute colitis in … WebJul 23, 2024 · Background. Polarized macrophage populations can orchestrate both inflammation of the kidney and tissue repair during CKD. Proinflammatory M1 macrophages initiate kidney injury, but mechanisms through which persistent M1-dependent kidney damage culminates in fibrosis require elucidation. Krüppel-like factor 4 (KLF4), a zinc … elevate whangarei

JCI - Krüppel-like factor 4 regulates macrophage polarization

Category:Klf4 Kruppel-like factor 4 (gut) [ (house mouse)] - National Center …

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Klf4 macrophage

Myeloid Krüppel-like factor 2 is a critical regulator of

WebOct 8, 2024 · The upregulation of macrophage makers is dependent on the transcription factor Klf4, but the exact mechanism for this activation of Klf4 has not previously been determined. 12 In this study, we demonstrate that cholesterol exposure activates all 3 pathways of the UPR and induces phenotypic switching primarily via the Perk-eIF2α-Atf4 … WebJan 1, 2024 · KLF4 is a bifunctional transcription factor, and its promotional and inhibitory functions in atherosclerosis depend on the target genes and target cells. KLF4 has a …

Klf4 macrophage

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WebApr 12, 2024 · These data suggest that KLF4 is a novel regulator of macrophage polarization. TAT- and Penetratin-linked Klf4 proteins can effectively replace viral Klf4 in … WebJan 25, 2024 · In young macrophages, the core molecular clock maintains healthy immune responses through KLF4. In aged macrophages, KLF4 activity diminishes despite a …

WebMar 2, 2024 · KLF4 expression was associated with immunological-related functions, infiltration of macrophages, CD8 + T cells, and other immune cells, and elevation of …

WebMacrophage KLF4 expression was robustly induced in M2 macrophages and strongly reduced in M1 macrophages, observations that were recapitulated in human … WebIn this regard, KLF4 has been shown to cooperate with STAT6 in promoting M2 macrophage polarization; deletion of the KLF4 gene in macrophages disrupts M2 function and increases proinflammatory gene expression . Moreover, the mouse KLF4 promoter contains CREB binding sites at −269 and −232 relative to the transcription start site.

WebOct 11, 2012 · We recently identified KLF4 as a regulator of macrophage subset specification; that is, KLF4 promotes M2 and inhibits M1 phenotype. Here, we provide evidence that KLF4-deficient macrophages exhibit enhanced proinflammatory activation and foam cell formation in response to oxidized lipids.

WebJan 1, 2024 · Under the influence of lipid peroxide, KLF4-deficient macrophages are easily transformed into foam cells. Experimental cell research has shown that KLF4-deficient macrophages exhibit enhanced foam cell formation and pro-inflammatory activation in response to lipid peroxide. elevate wellness health insuranceWebMay 18, 2015 · SMC-specific conditional knockout of Krüppel-like factor 4 ( Klf4) resulted in reduced numbers of SMC-derived MSC- and macrophage-like cells, a marked reduction in lesion size, and increases in... foot injuries listWebApr 13, 2024 · As an underlying anti-inflammatory factor, it has been reported that KLF4 can attenuate macrophages inflammation by inactivating NF-κB pathway and manage macrophages polarization, cells apoptosis and other biological activities [ 24 – 27 ]. elevate wellness shepherdsville kyWebNov 18, 2024 · Indeed, accumulation of macrophages around apoptotic adipocytes (forming CLS), leads to an increase in macrophage and neutrophil recruitment to the liver, … foot injuryWebMar 2, 2024 · KLF4 expression was associated with immunological-related functions, infiltration of macrophages, CD8 + T cells, and other immune cells, and elevation of immune checkpoints. Higher levels of CD8 + T cells and macrophage infiltration are associated with increased KLF4 expression in HCC TMA. elevate wellness spa ouray coWebApr 8, 2024 · The structure of the Klf4 DNA-binding domain links to self-renewal and macrophage differentiation. Cell Mol Life Sci. 2011;68:3121–31. Article CAS PubMed Google Scholar foot injury at workWebOct 15, 2024 · Highlights. Intraperitoneal injection of tamoxifen in peanut oil increases autofluorescence of adipose tissue macrophages causing false identification as eYFP + cells.. Single-cell RNAseq using Myh11-Dre ERT2 tdTomato mice given oral tamoxifen identifies 8 perivascular cell dominated clusters, half of which are altered upon diet … foot injuries side of foot