Irf4 pathway

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August undefined, 2024

WebInterferon regulatory factor 4 (IRF4) has critical roles in immune cell differentiation and function and is indispensable for clonal expansion and effector function in T cells. Here, we demonstrate that the AKT pathway is impaired in murine CD8 + T cells lacking IRF4. WebApr 11, 2024 · 多人被撤销基金项目！. 国家基金委公布一批科研不端案件处理结果. 2024-04-11 21:49:00 来源: 材料科学与工程北京举报. 371. 分享至. 2024年查处的不端行为案件处理结果通报（第一批次）. 近期，经国家自然科学基金委员会监督委员会调查审议、国家自然科学 …

国家自然基金委通报今年首批八起学术不端案件，七起涉“医”_科学 …

WebJul 1, 2016 · IRF4 has been identified as an important transcription factor for differentiation of T cells (Th2, Th9 and Th17) or B cells and is required for the function of Treg, thus … WebIRF8 and IRF4 are also involved in the regulation of B and T-cell development at multiple stages. IRF8 and IRF4 function redundantly to drive common lymphoid progenitors (CLPs) … dhc astaxanthin allinone collagen gel

LMP1 signaling pathway activates IRF4 in latent EBV infection and …

WebAug 14, 2024 · This proposed pro-inflammatory effect of IRF4 in macrophages was also surprising as IRF4 is usually considered to have an anti-inflammatory role in such cells since it down-regulates their production of pro-inflammatory cytokines such as TNF and IL-1β (99–101). Thus, GM-CSF joins the list of cytokines, such as IL-4 and TSLP, which can up ... WebApr 29, 2014 · IRF4 is composed of a single polypeptide chain containing two independent structural domains, a DNA-binding domain (DBD) and a regulatory domain (RD), which are separated by a flexible linker 11. The N-terminal DBD is highly conserved among IRFs. WebApr 4, 2024 · IRF4 Gene Expression on the Trail of Molecular Response: Looking at Chronic Myeloid Leukemia from Another Perspective. Interferon Regulatory Factor 4 (IRF4) … cif state meet cross country

JP7239597B2 - Regulators of IRF4 expression - Google Patents

多人被撤销基金项目！国家基金委公布一批科研不端案件处理结果

WebApr 30, 2009 · IRF4 (also known as pip, MUM1, LSIRF, NFEM5, and ICSAT) is an IRF-family member that is restricted in expression to the immune system, a property it shares with its closely related family member IRF8. IRF4 and IRF8 have evolved as critical mediators of lymphoid-, myeloid-, and dendritic-cell development ( 1 – 5 ). WebAug 1, 2024 · We demonstrated an IRF4‐mediated feedback signaling pathway between exercise and exercise‐induced exhaustion. When running, IRF4 was induced and then inhibited PTG‐associated glycogen synthesis, which eventually led to glycogen depletion and causing exhaustion. The glycogen contents in skeletal muscle was higher in MI4KO mice … cif state girls soccerWebFurther studies are required to elucidate the potential association between IRF4 expression and other inflammatory signaling pathways. In conclusion, our results indicate that IRF4 deficiency drives macrophage polarization toward M1 phenotype and increases the production of pro-inflammatory cytokines, which finally results in worsen ... cif state games

"WebJan 1, 2015 · IRF4 regulates MYC expression in ALCL. ALCL survival depends on IRF4/MYC signaling. Abstract Anaplastic large cell lymphoma (ALCL) is a distinct entity of T-cell lymphoma that can be divided into 2 subtypes based on the presence of translocations involving the ALK gene (ALK + and ALK − ALCL). " - Irf4 pathway

Irf4 pathway

JMJD3 in the regulation of human diseases SpringerLink

WebIrf4 is a critical regulator of many aspects of B- and T-cell differentiation and cell metabolism (Biswas et al., 2012; De Silva, Simonetti, Heise, & Klein, 2012; Eguchi et al., … WebJan 22, 2024 · Here, we show that class IA PI3K-mediated signals induce the expression of the transcription factor Pax5, which plays a central role in B cell commitment and differentiation by activating the...

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WebOverview. Interferon regulatory factor 4 (IRF4) is a gene that encodes a transcription factor protein that functions as a regulator of interferons and interferon-inducible genes. The … WebJun 1, 2016 · IRF4 siRNA transfection alters baicalin-induced macrophage subtype distribution. IRF4 siRNAs were transfected into mouse peritoneal macrophages. After 6 h, …

WebDec 3, 2024 · Fig. 7 ADK deficiency inhibits reparative macrophage polarization through the H3K4me3-IRF4 pathway. A, qPCR analysis of the mRNA level of Irf4 in BMDMs from Adk WT and Adk MAC-KO mice … WebIRF4. Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, [5] [6] [7] located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of human immune cells. [8] [9] The expression of IRF4 is essential for the differentiation of T lymphocytes and B ...

WebIRF4: A gene on chromosome 6p25-p23 that encodes a member of the interferon regulatory transcription factor (IRF) family, which is characterised by an unique tryptophan pentad …

WebMay 31, 2024 · IRF4 antagonizes IRF5 activation by competing with IRF5 for its interaction with MyD88 ( 33 ). IRF3, which is activated via cytosolic RIG-I-like receptors (RLRs), binds dominantly to the promoter region of the gene encoding the p40 subunit of interleukin 12 ( Il12b) and interferes with the binding of IRF5, which is activated via TLRs ( 49 ). c# if statement and orWebApr 11, 2024 · 2024年查处的不端行为案件处理结果通报（第一批次）. 近期，经国家自然科学基金委员会监督委员会调查审议、国家自然科学基金委员会委务会议审定，国家自然科学基金委员会对相关科研不端案件涉事主体进行了处理。. 现将给予通报批评的有关案情及处理 ... cif state girls basketball championshipsWebJun 21, 2024 · The TCR pathways leading to IRF4 are unclear, and our data shows for the first time that downstream of the TCR and ITK, the Ras/MAPK pathways leads to IRF4 … cif state meet swimmingWebIRF8 and IRF4 are also involved in the regulation of B and T-cell development at multiple stages. IRF8 and IRF4 function redundantly to drive common lymphoid progenitors (CLPs) to B-cell lineage. IRF8 and IRF4 are also required in the regulation of germinal center (GC) B cell differentiation. Role in Diseases [ edit] dhc astaxanthin reviewsWebAug 1, 2024 · Our study identifies IRF4 as the signaling node that regulates metabolic adaptation to extracellular stimuli; this is supported by our findings that IRF4 levels in … c# if statement alternativeIRF4 is an essential regulatory component at various stages of B cell development. In early B cell development, IRF4 functions alongside IRF8 to induce the expression of the Ikaros and Aiolos transcription factors, which decrease expression of the pre-B-cell-receptor. [9] See more Interferon regulatory factor 4 (IRF4) also known as MUM1 is a protein that in humans is encoded by the IRF4 gene, located at 6p25-p23. IRF4 functions as a key regulatory transcription factor in the development of … See more IRF4 is a transcription factor belonging to the Interferon Regulatory Factor (IRF) family of transcription factors. In contrast to some other IRF family members, IRF4 expression is not initiated by interferons; rather, IRF4 expression is promoted by a variety of bioactive … See more IRF4 has been shown to interact with: • Aiolos, • BATF3, • Blimp-1, See more • FactorBook IRF4 • IRF4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) This article … See more In melanocytic cells the IRF4 gene may be regulated by MITF. IRF4 is a transcription factor that has been implicated in acute leukemia. This gene is strongly associated with pigmentation: sensitivity of skin to sun exposure, freckles, blue eyes, and brown hair color. A … See more • Interferon regulatory factors See more • Mamane Y, Sharma S, Grandvaux N, Hernandez E, Hiscott J (January 2002). "IRF-4 activities in HTLV-I-induced T cell leukemogenesis". Journal of Interferon & Cytokine Research. 22 (1): 135–143. doi:10.1089/107999002753452746. PMID 11846984 See more dhc astaxanthin cream reviewWebSep 1, 2006 · IRF4 and IRF8 can function as transcriptional repressors when bound to an ISRE motif but as transcriptional activators when bound to an ETS/ISRE composite DNA … dhc at redbird