WebDescription. Potent, selective, and orally active anti-fibrotic JNK inhibitor (IC50 values 61 nM, 7 nM, 6 nM, 480 nM, and 3400 nM for JNK1, JNK2, JNK3, ERK1, and p38α, … WebARB IPF 930 Super Rally Driving Lights - Extra High Performance Dual Beam System,Designed For World Rally Championships,H4 Bulb Produces 100W Low And …
Idiopathische longfibrose - IPF online
Web1 feb. 2012 · Abstract. In this Letter we describe the discovery of potent, selective, and orally active aminopurine JNK inhibitors. Improving the physico-chemical properties as well as increasing the potency and selectivity of a subseries with rat plasma exposure, led to the identification of four structurally diverse inhibitors. WebPreclinical evidence suggests that JNK enzyme function is required for key steps in the pulmonary fibrotic process. However, a selective JNK inhibitor has not been investigated in translational models of lung fibrosis with clinically relevant biomarkers, or in IPF patients. Methods: The JNK inhibitor CC-930 was evaluated in the house dust mite ... ipl light hair removal factory
Idiopathische pulmonale fibrose - Wikipedia
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