Web5-hydroxyisourate hydrolase, HIU hydrolase, HIUHase, transthyretin-related protein. GeneRIFs: Gene References Into Functions. This review cites the remarkable changes of HIUase active sites during the evolution of transthyretin that gave rise to a channel open at both ends, thus allowing free access to hormone molecules. ... Web2 mei 2024 · The reaction is the first stage in the conversion of 5-hydroxyisourate into S-allantoin. This reaction will also occur spontaneously but more slowly. History. EC 3.5.2.17 created 2004. Pathway. ec00230. Purine metabolism. ec01100. Metabolic pathways.
Deficiency of 5-hydroxyisourate hydrolase causes …
Web29 aug. 2005 · Recently, the plant gene encoding hydroxyisourate hydrolase was identified from soybean (Glycine max) [13]. This gene encodes a protein that is 560 amino acids in length and contains a 31-amino acid signal sequence at N-terminus. The presence of two SKL motifs near C-terminus suggests that this HIUHase may reside in the … WebWe report the identification and purification of a novel enzyme from soybean root nodules that catalyzes the hydrolysis of 5-hydroxyisourate, which is the true product of the urate oxidase reaction. The product of this reaction is 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline, and the new enzyme is designated 5-hydroxyisourate hydrolase. … shanty hollow lake ky
Identification and Purification of Hydroxyisourate …
Web5 feb. 2006 · HIU hydrolase and OHCU decarboxylase are encoded by two ancient families of orthologous genes and are expected to function in purine metabolism in a variety of … WebHIU hydrolysis also occurs spontaneously, but more slowly. Catalytic activity 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5 … Web26 sep. 2024 · Summary Enables hydroxyisourate hydrolase activity. Involved in allantoin metabolic process; purine-containing compound catabolic process; and urate catabolic … shanty hilversum