Human timp-2

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August undefined, 2024

WebSimple plex assay for the detection of human Tissue Inhibitor of Metalloproteinases 2 (TIMP-2) in cell culture supernatant (CCS), serum, plasma (EDTA/Heparin), saliva, and … WebThe concentration of CHI3L1 was measured by a human sandwich enzyme-linked immunosorbent assay (ELISA) (DC3L10, R&D Systems, Minneapolis, MN, USA) validated for urine, whereas the Astute140 ® Meter measured the concentrations of urine TIMP-2, urine IGFBP7, and NephroCheck ® by a fluorescent immunoassay (NephroCheck ® …

TIMP2 - Wikipedia

WebTIMP2 Protein, Human, Recombinant. 10396-HNAH. High Purity. > 96 % as determined by SDS-PAGE. Low Endotoxin. < 1.0 EU per μg of the protein as determined by the LAL method. High Activity. Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate MCA-PLGL-DPA-AR-NH2 (R&D Systems, Catalog # … WebTimlog™ is a plant-based human TIMP-2 (Tissue inhibitor of metalloproteinases) produced in Wild plants as biofactories technology. TIMP-2 is an inhibitor of all MMPs (specifically of MMP-2). Additionally, it increases fibromodulin which has an important role in organizing the ECM by binding to collagen, resulting in delay of fibril formation ... earn 362 more points this

Human TIMP-2 Quantikine ELISA Kit - Novus Biologicals

WebLevels of MMP-2, TIMP-2, and TGF-β1 were determined by specific immunoassays (enzyme-linked immunosorbent assay). Results: MMP-2, TIMP-2, and TGF-β1 were identified in aqueous humor and serum samples from all groups of patients. The aqueous and serum samples of MMP-2, TIMP-2, and TGF-β1 showed no significant differences … WebNov 16, 2024 · Background: TIMP-2. Tissue inhibitors of metalloproteinases or TIMPs are a family of proteins that regulate the activation and proteolytic activity of the zinc enzymes … WebThe present specification discloses a novel use of granulocyte colony-stimulating factor receptor or colony-stimulating factor 3 receptor (CSF3R) as a biomarker and as a therapeutic target for pulmonary fibrosis. The present specification discloses a treatment mechanism, a treatment method, and a treatment drug involving CSF3R for pulmonary … earn 362 more points this month

Potential of Urine Biomarkers CHI3L1, NGAL, TIMP-2, IGFBP7, …

TIMP-2 antibody 8 (2 knockout-validated) products in Validated ...

WebDec 12, 2024 · Here we present a straightforward bioprocessing methodology that yields >35 mg/L recombinant human TIMP-2 6XHis-tagged protein (rhTIMP-2) from suspension cultures of HEK-293-F cells. Enhanced rhTIMP-2-6XHis yields were achieved by optimization of both TIMP-2 cDNA codon sequence and cell culture conditions. Using a … WebTIMP2 functions as both an MMP inhibitor and an activator. TIMPs inhibit active MMPs, but different TIMPs inhibit different MMPs better than others. For example, TIMP-1 inhibits MMP-7, MMP-9, MMP-1 and MMP-3 better than TIMP-2, and TIMP-2 inhibits MMP-2 more effectively than other TIMPs. [6] In melanocytic cells TIMP2 gene expression may be ... earn 32WebReferences for TIMP-2 antibody. Chu, S.C. et al. (2004) Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol … earn 3200 points

"WebJul 1, 2010 · Abstract. Matrix metalloproteinases (MMP) have been implicated in multiple stages of cancer metastasis. Tissue inhibitor of metalloproteinase-2 (TIMP-2) plays an important role in regulating MMP-2 activity. By forming a ternary complex with pro-MMP-2 and its activator MMP-14 on the cell surface, TIMP-2 can either initiate or restrain the … " - Human timp-2

Human timp-2

WebHuman TIMP-2 Quantikine ELISA Kit Summary Applications/Dilutions Packaging, Storage & Formulations Storage Store the unopened product at 2 - 8 °C. Do not use past expiration … WebTIMP 2; TIMP metallopeptidase inhibitor 2; TIMP-2; TIMP2; TIMP2_HUMAN; Tissue Inhibitor of Metalloproteinase 2; Tissue inhibitor of metalloproteinases 2; see all. Function. Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3 ...

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WebA recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 27-220 of Human TIMP-2. Source: E.coli Amino Acid Sequence: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMCS CSPVHPQQAF CNADVVIRAK AVSEKEVDSG NDIYGNPIKR IQYEIKQIKM FKGPEKDIEF IYTAPSSAVC … WebDec 27, 2024 · The Quantikine Human TIMP-2 Immunoassay is a 4.5 hour solid phase ELISA designed to measure TIMP-2 levels in cell culture supernates, serum, plasma, and saliva. It contains CHO cell-expressed recombinant human TIMP-2, and antibodies raised against the recombinant protein. Natural human TIMP-2 showed dose-response curves …

WebMar 25, 2024 · Detection of Human TIMP-2 by Western Blot. Western blot shows Recombinant Human TIMP-2 Western Blot Standard Protein (Catalog # WBC023 ) and lysates of HeLa human cervical epithelial carcinoma cell line and human placenta tissue. PVDF membrane was probed with 1 ╡g/mL of Goat Anti-Human/Mouse TIMP-2 Antigen … WebBiological activity. TIMP2 activity was measured by its ability to inhibit human MMP1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP2 concentration of approximately 0.5 µg/ml, when using an MMP1 concentration of 1.6 µg/ml.

WebRecombinant Human TIMP2 protein (ab287940) Datasheet Submit a review Submit a question $725 Product size 100 µg 50 µg $725 10 µg $410 Add to basket Order now and get it on Thursday March 02, 2024 Custom quote … WebTissue inhibitor of metalloproteinase-2 (TIMP2) is a 21 kDa protein mainly expressed in melanoma and renal tubular cells. TIMP2 inhibits matrix metalloproteinases by binding to …

WebMar 12, 2015 · Oncogenic miR-20a and miR-106a Enhance the Invasiveness of Human Glioma Stem Cells by Directly Targeting TIMP-2 Oncogene. 2015 Mar 12 ... isolated from both glioblastoma cell line U87 and primary human glioma specimens. We found that the level of miR-20a/106a in GSCs was significantly higher than that in the committed …

WebTIMP2 Protein, Human, Recombinant 10396-HNAH High Purity > 96 % as determined by SDS-PAGE Low Endotoxin < 1.0 EU per μg of the protein as determined by the LAL method High Activity Measured by its ability to inhibit human MMP-2 cleavage of a fluorogenic peptide substrate MCA-PLGL-DPA-AR-NH2 (R&D Systems, Catalog # ES001). The IC50 … earn 3 campaign decorationsWebDec 21, 2024 · The TIMP family consists of four members: TIMP-1, -2, -3 and -4. Whilst TIMPs are widely regarded as broad-range MMP inhibitors, each protein exhibits differences in their specificity. ... Similarly, collagen VI expression levels are higher in the brains of AD mice models and in human AD patients . Recent discoveries in cell biology and ... earn 362 more points this month to stay csv excel 文字化け pythonWebSimply select your targets of interest to find the assay that meets your needs. MMPs have many different functions and actions in the body, whereas TIMPs work to inhibit the actions of MMPs. Studying MMPs and their inhibitors, TIMPs, together can reveal disruptions in the balance of these two proteins, providing insights into disease states. csv error can\\u0027t read from csv fileWebELISA Human TIMP2 ELISA Kit (ab100653) Primary Anti-TIMP2 antibody (ab180630) Protein Recombinant human TIMP2 protein (ab82117) View more associated products … csv excel converter onlineWebThe RayBio ® Human TIMP-4 IQELISA™ Kit is a modified ELISA assay with high sensitivity qPCR readout for the quantitative measurement of Human TIMP-4 in serum, plasma, and cell culture supernatants. This assay employs an antibody specific for Human TIMP-4 coated on a 96-well PCR plate. Standards and samples are pipetted into the wells and ... earn 362 more points this month to stay levelWebMar 21, 2024 · TIMP1 (TIMP Metallopeptidase Inhibitor 1) is a Protein Coding gene. Diseases associated with TIMP1 include Oral Submucous Fibrosis and Conjunctivochalasis.Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and GPCR Pathway.Gene Ontology (GO) annotations related to this gene … csv example file download