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Gata1 transcription factor

WebJun 14, 2024 · The GATA1 gene encodes a zinc finger DNA-binding transcription factor that plays a critical role in the normal development of hematopoietic cell lineages. The … WebThe GATA family of transcription factors is comprised of six members characterized by their binding to the consensus DNA sequence (T/A)GATA(A/G). GATA1, which was the initially described member of the GATA family, is predominantly expressed in cells of the myeloid lineage such as erythrocytes, eosinophils, mast cells, and megacaryocytes.

髓系造血分化核心转录因子研究进展 - ResearchGate

WebOct 22, 2024 · GATA transcription factors are evolutionarily conserved among animals, plants and fungi. Vertebrates possess six paralogs, classified into two subfamilies based on their spatial and temporal expression patterns (Fig. 1A).Although originally divided as hematopoietic (GATA1/2/3) and cardiac (GATA4/5/6) GATA factors, their function and … WebInterestingly, we found GATA1 was the transcription factor (TF) of HNF1A-AS1. Previously, GATA1 has been unveiled to be overexpressed and also function as a TF in breast carcinomas. 34,35 Through mechanism experiments, we proved the interaction of GATA1 with HNF1A-AS1 promoter and also discovered that HNF1A-AS1 expression … rescued manatee https://jjkmail.net

Regulation of GATA1 levels in erythropoiesis

WebGATA1 is expressed in primitive and definitive erythroid cells (27, 55), megakaryocytes (61, 92), eosinophils (138), and mast cells (61) and in the Sertoli cells of the testis … Web作用,转录因子(transcription factor,TF)在造血分化过程中 发挥了核心调节作用,在多系分化方向关键点控制HSPC分 化命运。 WebTranscriptional activator or repressor which serves as a general switch factor for erythroid development ( PubMed: 35030251 ). It binds to DNA sites with the consensus sequence … pros and cons of being vegan and vegetarian

GATA1 - an overview ScienceDirect Topics

Category:General transcription factor - Wikipedia

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Gata1 transcription factor

The TAL1/SCL Transcription Factor Regulates Cell Cycle …

WebMar 21, 2024 · Entrez Gene Summary for GATA1 Gene. This gene encodes a protein which belongs to the GATA family of transcription factors. The protein plays an important role … WebApr 21, 2024 · GATA1 is the master erythroid transcription factor (TF). It is a 413-amino-acid-long protein with 2 zinc finger (ZnF) domains mapping to the C-terminal half of the …

Gata1 transcription factor

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WebA sigma factor is a protein needed only for initiation of RNA synthesis in bacteria. Sigma factors provide promoter recognition specificity to the RNA polymerase (RNAP) and … WebJul 1, 2024 · Loss of Full-Length GATA1 Expression in Megakaryocytes Is a Sensitive and Specific Immunohistochemical Marker for the Diagnosis of Myeloid Proliferative Disorder Related to Down Syndrome. Lee WY et al: 15895080: 2005: Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1. Li Z et al: …

WebMar 30, 2024 · GATA-1, the founding member of a distinctive family of transcription factors, is expressed predominantly in erythroid cells and participates in the expression … WebIn molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. The function of TFs is to regulate—turn on and off—genes in order to make sure that they are expressed in the …

WebApr 13, 2024 · The GATA transcription factor family Mammalian genomes encode six structurally related members of the GATA family, which function as tissue-specific master … WebAug 2, 2024 · Our findings show that GATA1 and NF-Y activate γ-globin expression, consolidating previous studies implicating these transcription factors and their respective cis elements in the expression of ...

WebGATA transcription factor s are a family of transcription factors characterized by their ability to bind to the DNA sequence "GATA". [1] GATA transcription factors have been correlated to their broader influence on stem cell development. Findings however, have pointed to a more direct influence by GATA transcription factors, as they are salient ...

WebSpecific research interests include the role of the N-terminal domain of the GATA1 transcription factor and the genetic contributions toward the … pros and cons of being vegetarian for kidsWebJan 20, 2024 · Papadopoulos, P. et al. TAF10 interacts with the GATA1 transcription factor and controls mouse erythropoiesis. Mol. Cell. Biol. 35, 2103–2118 (2015). rescued mastiffWebGATA transcription factors are required for the differentiation of diverse cell types in several species. Recent evidence suggests that their biologic activities may be modulated through interaction with multitype zinc finger proteins, such as Friend of GATA-1 (FOG) and U-shaped (Ush). In cell culture, FOG cooperates with the hematopoietic ... rescued meansWebRegulation of gene expression during the ontogeny of haematopoiesis in the human fetal bone marrow is poorly understood. Studies in mice demonstrated that GATA-1, -2 and -3 play pivotal roles in haematopoiesis. In this study, we identified GATA-1-, GATA-2- and GATA-3-expressing cells in bone marrow … rescued miniature horsesrescued mini-horse cuddling teddy bearWebThe transcription factor GATA1 coordinates timely activation and repression of megakaryocyte gene expression. Loss of GATA1 function results in excessive megakaryocyte proliferation and disordered te pros and cons of belbin\u0027s theoryWebAug 1, 2012 · GATA binding protein 1 (GATA1, GenBank ID: NM_002049) is a key haematopoietic transcription factor with a pivotal role in differentiation of the erythroid, megakaryocyte, eosinophil and mast cell lineages[].The GATA1 gene produces at least two protein isoforms—the well characterised GATA1 full-length (GATA1FL) isoform and a … pros and cons of belgian malinois