Cholangioids
WebMar 3, 2024 · To examine this concept, we cultured epithelial cell adhesion molecule–positive reactive cholangioids (ERCs) obtained from wild-type (WT), Tr −/−, Mdr2 −/− and DKO mice. Single-cell transcriptomics and immunostaining of both WT and DKO ERCs confirmed their DR-cell phenotype. WebSep 27, 2024 · Major physiologic functions of cholangiocytes include modification of the bile, the formation of a barrier between biliary constituents in the bile duct lumen and the tissue surrounding the bile duct, and providing access to the immune and vascular systems in the peribiliary space.
Cholangioids
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WebApr 10, 2024 · Similarly, in a 3D organoid model using PSC cholangiocytes, these “cholangioids” displayed senescent and SASP features, which promoted macrophage recruitment and number. The role of senescence/SASP in biliary injury has been demonstrated; thus, evaluation of targeting this axis for therapeutic use is of great interest. WebWe use these models to investigate whether PSC cholangiocytes are intrinsically predisposed to cellular senescence. Skin fibroblasts from healthy controls and subjects …
WebMy Research and Language Selection Sign into My Research Create My Research Account English; Help and support. Support Center Find answers to questions about products, access, use, setup, and administration.; Contact Us Have a question, idea, or some feedback? We want to hear from you. WebAug 25, 2024 · Comparison of cholangioids from iPSC-derived iDCs. (A) Top to bottom view of cholangioids from healthy control and PSC iDCs from patient 3 (left), fold …
WebAdditional file 6: Figure S3. hPMSCs culture and identification. (a) Picture of hPMSCs captured by light microscope: classic spindle-shaped morphology (scar bar, 100 μm); (b) Alizarin red S staining of hPMSCs on day 21(scar bar, 100 μm); (c) Oil red O staining of hPMSCs on day 28 (scar bar, 100 μm). (d) Flow cytometry analysis of surface antigens … WebAcute cholangitis is inflammation of biliary ductal system from infection with an associated biliary obstruction. This retrospective study was done to determine the factors responsible for cholangitis and the microbiological profile of the bile in patients with cholangitis.
WebCholangioids are functionally active, and upon secretin stimulation, luminal size increased by ~80%. Cholangioids exposed to hydrogen peroxide exhibited cellular senescence …
WebCholangioids are functionally active, and upon secretin stimulation, luminal size increased by ~80%. Cholangioids exposed to hydrogen peroxide exhibited cellular senescence … rawlings select pro lite youth baseball gloveWebDevelopment and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis. Lorena Loarca, Thiago M. De Assuncao, Nidhi Jalan-Sakrikar, Steve Bronk, Anuradha Krishnan, Bing Huang, Leslie Morton, Christy Trussoni, Lorena Marcano Bonilla, Eugene Krueger, ... simple green on glasshttp://lcgdbzz.org/en/article/doi/10.3969/j.issn.1001-5256.2024.08.035 rawlings semi relaxed youth baseball pantsWebMar 22, 2024 · Cholangioids were collected and analyzed at 48, 72, and 120 h. e Presence of the exosome-specific marker CD9 (red) in cholangioids (CK19, green) of the Exo … simple green on leatherWebJul 1, 2007 · Development and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis Laboratory Investigation, Volume 97, Issue 11, 2024, pp. 1385-1396 Show abstract Research article rawlings select pro lite glove seriesWebDevelopment and characterization of cholangioids from normal and diseased human cholangiocytes as an in vitro model to study primary sclerosing cholangitis. Lorena … simple green on leather couchWebConclusion: We demonstrated efficient generation of iDCs and cholangioids from patients with PSC that show disease-specific features. PSC cholangiocytes are intrinsically … simple green® original - 55 gallon drum