Canine model of pacing-induced heart failure

Author: acec

August undefined, 2024

WebHeart failure with reduced ejection fraction (HFrEF) is defined by an ejection fraction (EF) below 40%. Many distinct disease processes culminate in HFrEF, among them acute and chronic ischemia, pressure … WebBackground Heart failure increases autonomic nerve activities and changes intracellular calcium (Ca i ) dynamics. Objective The purpose of this study was to investigate the hypothesis that abnormal Ca i dynamics are responsible for triggered activity in the pulmonary veins (PVs) during acetylcholine infusion in a canine model of heart failure.

Chronic heart failure selectively induces regional heterogeneity of ...

WebFeb 1, 2004 · Heart failure was induced in 15 dogs over 27 days by rapid pacing (230 beats/min). Seven animals underwent sham surgery, and 8 animals received 3 transventricular Myosplint devices each. WebJul 10, 2024 · The development of pacing-induced heart failure was studied in chronically instrumented, conscious dogs paced at a rate of 240 beats/min for 1 d (n = 6), 1 wk (n = … dwyer high school football players in nfl

Atrial fibrosis and the mechanisms of atrial fibrillation

WebDec 1, 2010 · Canine model of pacing-induced HF. All animal study protocols were approved by the Institutional Animal Care and Use Committee of Indiana University … WebTo further understand the cellular events and to clarify their role in the pathology of cardiac failure, we have examined mitochondrial enzymatic function and peptide content, and mitochondrial DNA (mtDNA) integrity in a canine model of pacing-induced cardiac failure. Methods: Myocardium and skeletal muscle tissues were evaluated for levels of ... crystal meth london

JCDD Free Full-Text Noncoding RNAs as Key Regulators for …

Ca2+ clock malfunction in a canine model of pacing …

WebMyocardial Akt levels were elevated in early heart failure (after 1-2 weeks of pacing) accompanied by increased levels of oxidative stress, cytokine tumor necrosis factor-alpha (TNF-alpha) and free fatty acid accumulation, reduced activity levels of mitochondrial respiratory complexes III and V and apoptosis initiation. WebJun 13, 2005 · Animal Model Preparation. All procedures were approved by the Indiana University Institutional Animal Care and Utilization Committee. The study was performed in a canine model of healed myocardial infarction (MI) and pacing-induced heart failure (HF) that was shown to have a high incidence of spontaneous ischemic ventricular … crystal meth lyricsWebThe mechanisms of sinoatrial node (SAN) dysfunction in heart failure (HF) remain unclear. We hypothesized that impaired rhythmic spontaneous sarcoplasmic reticulum Ca(2+) … crystal meth mischkonsum

"WebThe LVEDP increased and impedance decreased during pacing-induced heart failure and recovered after pacing cessation. At the end of pacing, there was a mean impedance reduction of 10.6 +/- 8.3% and a mean LVEDP increase of 18.1 +/- 4.5 mmHg compared to baseline. The impedance and LVEDP were inversely correlated (r =-0.41 to -0.85, all P < … " - Canine model of pacing-induced heart failure

Canine model of pacing-induced heart failure

$Effective Refractory Period - an overview ScienceDirect Topics$

WebChronic heart failure is a clinical syndrome with multiple etiologies, associated with significant morbidity and mortality. Cardiac arrhythmias, including ventricular tachyarrhythmias and atrial fibrillation, are common in heart failure. A number of cardiac diseases including heart failure alter the expression and regulation of ion channels and … WebThis model typically produces heart failure as defined by an LV dP/dt max <1500 mmHg/s, end-diastolic pressure >25 mmHg, mean arterial pressure <85 mmHg, and an ejection …

Did you know?

WebIn studies aimed at characterizing the canine pacing-induced heart failure model further, it was demonstrated that atrial ERP was unchanged prior to the initiation of AF (Li et al., 1999). The extent of atrial fibrosis, however, was increased dramatically (from 0.3% in control to ∼15% in animals in congestive heart failure), a structural ... WebDec 4, 2014 · In dogs with heart failure induced by 6 weeks of atrial tachy- pacing, PITA (starting on week 3) suppressed progressive cardiac …

WebAug 17, 2011 · In addition, Nikolaidis et al. reported a 31% reduction in GLUT4 translocation and subsequently decreased glucose uptake, which was attributed to myocardial insulin resistance in their canine model of pacing-induced end-stage HF. However, it should be noted that their animal model was paced for a shorter duration (35 days) and at a ... WebMay 10, 2016 · In pacing-induced canine models of heart failure, marked upregulation of adenosine A1 receptors occurs with increased sensitivity to adenosine induced SN dysfunction and AF. 67. Download figure; Download PowerPoint; Figure 4. Rhythm strip showing the effect of adenosine on the sinus node and atrium. Intravenous adenosine …

WebJan 31, 2024 · The Impact of Renal Denervation on the Progression of Heart Failure in a Canine Model Induced by Right Ventricular Rapid Pacing The Impact of Renal Denervation on the Progression of Heart Failure in a Canine Model Induced by Right Ventricular Rapid Pacing Front Physiol. 2024 Jan 31;10:1625. doi: … WebJul 10, 2024 · Pacing-induced heart failure in the dog recapitulates many of the electrophysiological and hemodynamic abnormalities of the human disease; however, the mechanisms underlying altered Ca2+ handling ...

WebJan 31, 2024 · Heart failure (HF) has been proposed as a potential indication of renal denervation (RDN). However, the mechanisms enabling RDN to attenuate HF are not well understood, especially the central …

WebTachypacing-induced heart failure is a well-established large animal model that recapitulates numerous pathophysiological, structural and molecular features of dilated … crystal meth meaningWebJun 1, 1999 · In the canine pacing model, we first reported the appearance of interstitial edema and disruption/disappearance of collagen fibers in the hearts of these animals as … dwyer high school football scheduleWebJan 20, 1998 · Pacing-induced heart failure is characterized by defects in nitric oxide generation, 14 and this alteration may increase the respiratory activity of mitochondria … crystal meth long term use effects on brainWebTachypacing-induced heart failure is a well-established large animal model that recapitulates numerous pathophysiological, structural and molecular features of … crystal meth molecular structureWeb20 hours ago · Abnormal mitochondrial function in myocardium of dogs with chronic heart failure. J Mol Cell Cardiol. 1998; 30:1757–1762. doi: 10.1006/jmcc.1998.0739 Crossref Medline Google Scholar; 105. Marin-Garcia J, Goldenthal MJ, Moe GW. Abnormal cardiac and skeletal muscle mitochondrial function in pacing-induced cardiac failure. … crystal meth long term effectsWebFeb 18, 2014 · In addition, a model of pacing-induced heart failure was employed to examine conditions of CHF and the results may be different in heart failure of a different origin. Conclusion. The present data demonstrate for the first time that a fast phase-III repolarization was associated with a low proarrhythmic potential in CHF, whereas a more … dwyer high school lacrosseWebBackground: The canine model of pacing-induced heart failure is characterized by an absence of ventricular hypertrophy despite severe hemodynamic stress and neurohormonal activation. Given the mode of ventricular pacing, hypertrophy might occur in the atrial appendage. Methods and results: Seventeen dogs underwent continuous right … crystal meth meetings