WebDec 20, 2024 · In addition to cancer treatment, Brd4 inhibitors have been studied in animal models for the treatment of inflammatory diseases, such as sepsis, multiple sclerosis and liver fibrosis that have been ... WebBRD4 was upregulated in fibrotic kidneys of mice after UUO surgery. • ZLD2218 was synthesized and evaluated as a BRD4 inhibitor with the IC 50 of 107 nM. • ZLD2218 alleviated kidney injury and fibrosis of UUO mice. • BRD4 inhibition by ZLD2218 might be a therapeutic for kidney injury and fibrosis.
BRD4 mediates NF-κB-dependent epithelial …
WebMay 14, 2024 · The therapeutic potential of BRD4 in cardiovascular disease. Shigang Lin &. Lizhong Du. Hypertension Research 43 , 1006–1014 ( 2024) Cite this article. 533 … WebMay 13, 2024 · Our data suggests that BRD4 positively regulates MK2 expression in CD. Further, BRD4-MK2 signaling is critical to profibrotic activation of mesenchymal cells in CD and is a potential therapeutic target to reverse CD-associated fibrosis. This is the full abstract presented at the Experimental Biology meeting and is only available in HTML … taxman change of address
Frontiers Hepatic BRD4 Is Upregulated in Liver Fibrosis of Variou…
WebAug 1, 2013 · These data suggest that Brd4 inhibitors represent a novel therapeutic option for IPF and potentially for other fibrotic indications. Materials and Methods Human Lung … WebJan 1, 2024 · BRD4 inhibition has been played a crucial role in relieving pathological cardiac hypertrophy 19, 20, cardiac remodeling 21, heart failure 21, atherosclerosis 14 and fibrosis 22, 23.Research and development of BRD4 inhibitors and its underlying mechanism exploration in cardiovascular diseases have become a hot spot 24, 25.Cardiac fibrosis … WebCardiac fibrosis (CF), a process characterized by potentiated proliferation of cardiac fibroblasts and excessive secretion and deposition of extracellular matrix (ECM) from the cells, contributes strongly to the pathogenesis of a series of cardiovascular (CV) diseases, including AMI, heart failure a … the clear institute for scoliosis